|Neurobiology of Rhythms|
|Team "Circadian clocks & metabolism"|
Background and objectives:
The mammalian circadian system comprises a network of endogenous circadian clocks that generate, via their outputs, an internal rhythmicity. At the top of the circadian system is a master clock located in the suprachiasmatic nuclei of the hypothalamus (SCN). Many circadian rhythms in behavior (e.g., the sleep–wake cycle) and physiology (e.g., cyclic hormonal secretion, such as pineal melatonin or adrenal glucocorticoids) are controlled by this key structure. The suprachiasmatic clock is mainly synchronised (reset) by ambient light cues. Moreover, non-photic factors, such as metabolic or arousing cues, can also feedback to the main circadian clock in constant darkness or modulate its synchronisation to light. Furthermore, mealtime is a potent synchronizer of secondary clocks in central (e.g., the cerebellum) and peripheral structures (e.g., the liver).
Our team investigates functioning of the cerebral clocks and their resetting by feeding, metabolic and arousing signals with an integrative approach combining molecular biology and comparative physiology. Our main goal is to identify the pathways through which the brain clocks control the rhythmicity of physiological processes, such as the daily feeding/fasting cycle and meal anticipation, and how they are regulated by feeding and arousing cues.
Group leaders: Patrick VUILLEZ & Etienne CHALLET
Group leaders: Sylvie RAISON & Etienne CHALLET
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