|Neurobiology of Rhythms|
|Team "Circadian clocks & metabolism"|
Functional links between the circadian system and structures regulating arousal and energy metabolism
A clear phase opposition of food intake and sleep/wake cycle distinguishes diurnal and nocturnal species. Nevertheless, neither the anatomical substrate, nor the cellular/molecular mechanisms that explain this different temporal organisation are currently well characterised. This specificity may be due to the way target structures integrate circadian signals and to different feedback from internal signals to the master clock in the suprachiasmatic nuclei (SCN).
Circadian desynchronisation induced, for instance, by shift work or chronic jet-lag has been associated with increased metabolic risks (overweight, high fasting glucose) and sleep disturbances, leading to the concept of "chronobesity".
in collaboration with Dominique Ciocca (Chronobiotron)
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