INCI » Contrôle Peptidergique des Emotions

Contrôle Peptidergique des Emotions

Responsable : Alexandre CHARLET

Nos travaux portent sur la compréhension des mécanismes cellulaires qui sous-tendent la régulation de nos émotions, de l’interaction sociale à la douleur, en passant par l’anxiété. Nous nous efforçons d’explorer comment les neuropeptides modulent l’activité des réseaux neurogliaux dans des structures clefs de l’intégration émotionnelle, telle que l’amygdale. Pour ce faire, nous combinons des approches ex vivo et in vivo d’électrophysiologie et d’imagerie autour d’outils génétiques.

Projets de l’équipe

Modulation ocytocinergique des réseaux astro-neuronaux
Alexandre Charlet

Circuits neuronaux ocytocinergiques
Alexandre Charlet

Membres

Chercheurs / Enseignants-chercheurs

Alexandre Charlet

Pascal Darbon

Doctorants

Angel Boudon

Etienne Clauss-Creusot

Valentin Grelot

Post-Doctorants

Olga Lapies

Kai-Yi Wang

Collaborateurs

Prof. Hibert group understanding the architecture of G-protein coupled receptors, University of Strasbourg, France
Prof. Grinevich group central mechanisms of stress responses, Mannheim University, Germany
Prof. Javier Stern group CNS mechanisms in cardiometabolic diseases, Georgia State University, USA
Prof. Bice Chini group Neurobiology of oxytocin and vasopressin receptors, CNR Neuroscience Institute, Milan, Italy.
Dr. Nathalie Rouach group neuroglial interactions in cerebral physiopathology, Collège de France, Paris, France.
Prof. Marc Landry, Bordeaux, France; Prof Andrew Gundlach, Melbourne, Australia.
Prof. Andrew Gundlach group peptide neurobiology, Florey Institute of Neuroscience and Mental Health, Australia.
Prof. Landry group purinergic-mediated neuroinflammation and brain disorders, UMR5293, Bordeaux, France.
Dr. Yalcin group neuroanatomy, pain and psychopathology, UPR3212, Strasbourg, France.
Prof Marcel Hibert, Strasbourg, France; Benephyt startup.
Dr. Simonin group GPCRs, pain and inflammation, UMR7242, Strasbourg, France.
Dr. Bihel group chemogenomic and medicinal chemistry, UMR7200, Strasbourg, France.
Benephyt startup, France.

Publications choisies

Toutes nos publications

Wahis J*, Baudon A*, Althammer F*, Kerspern D*, Goyon S, Hagiwara D, Lefèvre A, Barteczko L, Boury-Jamot B, Bellanger B, Abatis M, Silva da Gouveia M, Benusiglio D, Eliava M, Rozov A, Weinsanto I, Knobloch-Bollmann HS, Kirchner MK, Roy RJ, Wang H, Pertin M, Inquimbert P, Pitzer C, Siemens J, Goumon Y, Boutrel B, Lamy CM, Décosterd I, Chatton J-Y, Rouach N, Young SW, Stern JE, Poisbeau P, Stoop R, Darbon P, Grinevich V, Charlet A. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. (Nature Neuroscience, in press).

Tang Y*, Benusiglio D*, Lefevre A*, Hilfiger L*, Althammer F, Bludau A, Hagiwara D, Baudon A, Darbon P, Schimmer J, Kirchner MK, Roy RK, Wang S, Eliava M, Wagner S, Oberhuber M, Conzelmann KK, Schwarz M, Stern JE, Leng G, Neumann ID, Charlet A#, Grinevich V#. Social touch promotes 1 inter-female communication via activation of parvocellular oxytocin 2 neurons. Nature Neuroscience, Nature Neuroscience 23(9):1125-1137.

Hilfiger L, Zhao Q, Kerspern D, Inquimbert P, Andry V, Goumon Y, Darbon P, Hibert M, Charlet A. (2020) A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain. Scientific Report, Feb 20;10(1):3017

Hasan MT*, Althammer F*, Silva da Gouveia M*, Goyon S*, Eliava M, Lefevre A, Kerspern D, Schimmer J, Raftogianni A, Wahis J, Knobloch-Bollmann HS, Tang Y, Liu X, Jain A, Chavant V, Goumon Y, Weislogel J-M, Hurlemann R, Herpertz SC, Darbon P, Dogbevia GK, Bertocchi I, Larkum ME, Sprengel R, Bading H, Charlet A#, Grinevich V#. (2019). Fear Memory Engram and its Plasticity in the Hypothalamic Oxytocin System. Neuron, 103(1):133-146.

Charlet A, Grinevich V. Oxytocin Mobilizes Midbrain Dopamine toward Sociality. Neuron. 2017 Jul 19;95(2):235-237.

Eliava M*, Melchior M*, Knobloch-Bollmann HS*, Wahis J*, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demoulire N, Busnelli M, Chini B, Tan L, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A#, Grinevich V#. A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and acute pain processing. Neuron (2016); 89: 1291-1304 (* co-first author; # co-corresponding and senior author)”