Horloge circadienne, sommeil et plasticité homéostatique dans les troubles de l’humeur
Responsable : Tsvetan Serchov
En utilisant une combinaison de méthodes de biologie moléculaire, d’électrophysiologie in vivo et d’analyses comportementales complexes, nos objectifs sont :
- Étudier le rôle de l’horloge circadienne dans la physiopathologie et le traitement de la dépression.
- Caractériser l’interaction entre les mécanismes circadiens et d’homéostasie du sommeil sur la signalisation glutamatérgique dans la thérapie antidépressive rapide.
- Étudier l’impact de la signalisation adénosinergique médiant les effets de la perte de sommeil sur l’humeur.
Membres
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Dr. Tsvetan Serchov, PhD, HDR 03 88 45 66 12 serchov@inci-cnrs.unistra.fr |
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Wilf Gardner |
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David Sarrazin |
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Carole Marchese |
Prof. Dr. Claus Normann (Psychiatry, Uniklinik Freiburg)
Prof. Dr. Volker A. Coenen (Neurozentrum, Uniklinik Freiburg)
Prof. Dr. Bernd Fakler (Physiology, University Freiburg)
Approches méthodologiques :
Genetically modified mouse models
Quantitative PCR, SDS-PAGE, Western blotting, Immunohystochemistry
Classical behavioral tests and complex automatic behavioral modeling and analyses via IntelliCage
In Vivo Electrophysiology: LFP and EEG (sleep) recordings
Financements :
Fondation pour la Recherche Medical (FRM)
University of Strasbourg Institute for Advanced Studies (USIAS)
German Research Foundation (DFG)
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Publications choisies
van Calker D, Serchov T*. (2021) The “Missing Heritability”-Problem in Psychiatry: Is the interaction of Genetics, Epigenetics and Transposable Elements a potential solution? Neurosci Biobehav Rev. S0149-7634 (21) 00134-2. doi: 10.1016/j.neubiorev. 2021.03.019.
Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E. (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell. 184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034.
Sun L, Verkaik-Schakel RK, Biber K, Plösch T, Serchov T* (2021) Antidepressant treatment is associated with epigenetic alterations of Homer1 promoter in a mouse model of chronic depression J Affect Disord. 279:501-509, doi: 10.1016/j.jad.2020.10.040.
Serchov T*, Schwarz I, Theiss A, Sun L, Holz A, Döbrössy MD, Schwarz MK, Normann C, Biber K, van Calker D. (2019) Enhanced adenosine A1 receptor and Homer1a expression in hippocampus modulates the resilience to stress-induced depression-like behavior. Neuropharmacology. 107834. doi: 10.1016/j.neuropharm.2019.
Holz A, Mülsch F, Schwarz MK, Hollmann M, Döbrössy MD, Coenen VA, Bartos M, Normann C, Biber K, van Calker D, Serchov T*. (2019) Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. Neuron. pii: S0896-6273(19)30637-3. doi: 10.1016/j.neuron.2019.07.011.
van Calker D, Biber K, Domschke K, Serchov T*. (2019) The Role of Adenosine Receptors in Mood and Anxiety Disorders. J Neurochem. doi: 10.1111/jnc.14841.
Serchov T, Clement HW, Schwarz MK, Iasevoli F, Tosh DK, Idzko M, Jacobson KA, de Bartolomeis A, Normann C, Biber K, van Calker D. (2015) Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. Neuron. 87(3):549-62. doi: 10.1016/j.neuron.2015.07.010.
